Two different factors act separately or together to specify functionally distinct activities at a single transcriptional enhancer.
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چکیده
منابع مشابه
Myosins pull together—separately
D on’t tell your high school football coach, but it is possible to have teamwork even if nobody’s in charge. Inside a cell, for example, myosin VI motors work in concert to haul cargoes along the actin cytoskeleton, Sivaramakrishnan and Spudich reveal (1). Instead of providing muscle power, myosin VI is one of the unconventional myosins whose job is intracellular transportation. Researchers hav...
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Actin filaments assemble into a variety of networks to provide force for diverse cellular processes [1]. Tropomyosins are coiled-coil dimers that form head-to-tail polymers along actin filaments and regulate interactions of other proteins, including actin-depolymerizing factor (ADF)/cofilins and myosins, with actin [2-5]. In mammals, >40 tropomyosin isoforms can be generated through alternative...
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Canada's provincial and territorial governments have expressed an interest in bulk purchasing prescription drugs for many years. We propose they start by purchasing selected generic drugs for the entire population and provide them for little or no cost to patients. This politically popular strategy would significantly reduce drug expenditures and improve population health.
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Three different alleles of the Hoxb4 locus were generated by gene targeting in mice. Two alleles contain insertions of a selectable marker in the first exon in either orientation, and, in the third, the selectable marker was removed, resulting in premature termination of the protein. Presence and orientation of the selectable marker correlated with the severity of the phenotype, indicating that...
متن کاملDifferent levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos.
The terminal portions of the Drosophila body pattern are specified by the localized activity of the receptor tyrosine kinase Torso (Tor) at each pole of the early embryo. Tor activity elicits the transcription of two 'gap' genes, tailless (tll) and huckebein (hkb), in overlapping but distinct domains by stimulating the Ras signal transduction pathway. Here, we show that quantitative variations ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1986
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.6.4.993